Endocrine Abstracts

Introduction: Type 2 diabetes mellitus (T2DM) is a risk factor for osteoporotic fractures although bone mineral density is increased. As such, there is a need for improved approaches to estimate fracture risk in such individuals. The Trabecular Bone Score (TBS) is a new technique to determine the trabecular bone microarchitecture.Objective: Our aim was to evaluate evaluate the usefulness of TBS in T2DM patients.Methods: We compared...

Introduction: A increased prevalence of metabolic syndrome (MetS) has recently been described in patients with adult growth hormone deficiency (GHD). This fact could influence the increased risk of cardiovascular morbidity and mortality observed in these patients. Our objective was to investigate the characteristics and prevalence of MetS in adult GHD.Design and methods: Forty-nine adult patients (30 women, 19 men; 14 childhood-onset), mean age of 36.2&#...

Background: Fine Needle Aspiration (FNA) is currently the primary diagnostic procedure in diagnosing thyroid malignancy. The aim of this study was to report our experience with FNA, and its accuracy.Materials and methods: Retrospective analysis of 166 patients who were operated of thyroid nodule in our hospital from 2003 to 2008, all of them had a previous FNA cytology results. There were evaluated some clinical variables and the correlation with final h...

Objetive: Obesity is associated with lower serum vitamin D (25(OH)D3) levels through several mechanisms. The aim of the study was to determine the prevalence of vitamin D deficiency and to examine the association between insulin resistance and 25(OH)D3 levels in a cohort of obese subjects.Materials and methods: 85 obese subjects were enrolled into the study from october to december 2018. Demographic, anthropometric and clinical para...

Objective: To evaluate the baseline characteristics and their evolution three months after implantation of the Flash glucose monitoring System (Freestyle Libre), after financing by the Andalusian Health Service in patients under 18 years old with type 1 diabetes mellitus (DM1) in our hospital area.Material and Methods: A descriptive observational and retrospective study that includes patients with DM1 under 18 years old from the southern hospital area of...

Objectives: Assess the canagliflozin effect on the ABPI in patients without previous treatment with iSGLT-2 as a possible etiology of tissue hypoperfusion and a risk factor for amputations.Material and methods: Prospective observational study where we analyzed patients diagnosed of type 2 diabetes mellitus (DM2) with poor metabolic control and without prior treatment with iSGLT-2, which is initiated treatment with canagliflozin. Clinical, biochemical par...

Objective: This study aims to assess the utility of salivary cortisol (SC) in diagnosing adrenal insufficiency (AI) and to analyze the integrity of the hypothalamic-pituitary-adrenal axis. This involves evaluating cortisol rhythm, its correlation with plasma levels, and the impact of exogenous hydrocortisone (HC) substitution on SC determination.Methods: A prospective study was conducted on all patients with suspected AI undergoing adrenocorticotropic ho...

Introduction: Pituitary adenomas are neoplasms originating in the pituitary gland. They represent 15.5% of tumor pathology of the central nervous system and their incidence is estimated at 3.4 cases per 100,000 inhabitants/year.Objective: To evaluate the postoperative results of adenomas operated on at the Hospital Clinico de Valladolid (HCUV) Material and Methods: Observational, transversal and retrospective study of operated aden...

Pituitary apoplexy (PA) is a rare syndrome that requires urgent assistance. It is due to ischemia or hemorrhage of pituitary tissue, almost always inside a pituitary tumor. PA may be the first manifestation of a neuroendocrine tumor or occur during follow up.Objective: To describe the characteristics of patients with PA treated in the Department of Endocrinology and Nutrition in the last 10 years and study the presence of possible risk factors for it.</p...

Introduction and Objetive: The composition of human gut microbiota is an emerging field of research and is currently regarded as pathophysiologically linked to obesity. However, we still lack a thorough understanding of what constitutes health and disease in this subject. We present herein a descriptive study of the gut microbiota composition among Spanish morbidly obese subjects, clustered regarding the carbohydrate metabolism status (CHMS) displayed.Me...